Conventional control of phosphate, calcium, and PTH has not closed the excess cardiovascular and fracture risk gap in CKD/ESKD, prompting exploration of alternative MBD pathways. FGF23 rises early in ...
Chronic kidney disease (CKD) has emerged as a global health challenge, largely due to its profound impact on mineral metabolism. Disruption of the tightly regulated balance of phosphate, calcium and ...
The US Food and Drug Administration (FDA) has added a boxed warning to the label of the osteoporosis drug denosumab (Prolia) about increased risk for severe hypocalcemia in patients with advanced ...
Colored x-ray of the pelvic region shows a fractured femur (red) caused by a fall. A lack of clinical trials and limited pharmaceutical options mean that management of this complication poses ...
Credit: Getty Images In a study, intact parathyroid hormone levels below 60 and above 1500 pg/mL were associated with nearly double the risk of all-cause mortality. High or low levels of calcium, ...
A coalition of leading inTernational experts in nephrology, bone health, and musculoskeletal disease has released the first comprehensive consensus statement on the management of vertebral fractures ...
The bisphosphonates are used widely in osteoporosis. In patients with stage 4 CKD, one small study found a modest increase in the bone density of the spine after 18 months, but no change in the hip. 7 ...
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