The clinical presentation of acute lymphoblastic leukemia (ALL) is generally nonspecific, and symptoms generally relate to anemia, thrombocytopenia and neutropenia due to the replacement of the bone ...

Although peripheral blasts with anemia and thrombocytopenia are strongly suggestive of ALL, the definitive diagnosis of ALL is based on the bone marrow aspiration or biopsy demonstrating more than 25% ...

What Is Acute Lymphoblastic Leukemia? Acute lymphoblastic leukemia (ALL) is a type of blood cancer that starts in white blood cells in your bone marrow, the soft inner part of your bones. It develops ...

To identify genomic determinants of relapse in children with SR ALL, we performed genome and transcriptome sequencing of diagnostic and remission samples of children with SR (n = 1,381) or high-risk B ...

In most cases, acute lymphoblastic leukemia (ALL) manifests as a de novo malignancy in previously healthy people. Risk factors for developing ALL include age older than 70 years and genetic disorders, ...

Hyperactive signaling pathways of some aggressive blood cancer cells can be tamped down by a previously unrecognized protein complex, ensuring the cancer's survival. If one component of the complex is ...

A combination of targeted treatment and immunotherapy has revolutionized Philadelphia chromosome–positive acute lymphoblastic leukemia management, achieving long-term survival rates of 75%-80% without ...

The American Society of Hematology (ASH) released guidelines on frontline management of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYAs), as well as the management of relapsed ...

Acute lymphoblastic leukemia (ALL) can lead to reduced production of healthy blood cells, increasing the risk of anemia, thrombocytopenia, and infections. Blood clots and central nervous system ...